Clowes was born in Chicago, Illinois, to an auto mechanic mother and a furniture craftsman father. His mother was Jewish, whereas his father was from a "reserved WASPish Pennsylvania" family; Clowes's upbringing was not religious. In 1979, he finished high school at the University of Chicago Laboratory Schools and attended the Pratt Institute in Brooklyn, New York, where he earned a BFA in 1984. It was at Pratt that he met and befriended fellow cartoonist Rick Altergott, with whom he started the...