Dr. Kay Redfield Jamison, a leading authority on depressive illnesses, shares her personal experience with manic-depression and a suicide attempt at age twenty-eight. This event propelled her life's work into understanding mental illness and self-inflicted death. Weaving together psychological and scientific exploration with personal essays, Dr. Jamison brings her compassion, research, and clinical experience to this devastating problem. She examines the reasons behind suicide, offering insights into methods, farewell notes, and the latest findings from global hospitals and laboratories, alongside new strategies and available treatments.