Robert Langdon wakes in a Florence hospital with a head wound, no memory of the past two days, and a stranger trying to kill him. A quick-thinking young doctor, Sienna Brooks, spirits him away, and the two discover a small biohazard cylinder hidden among his belongings—one that projects a modified version of Botticelli's Map of Hell, itself inspired by Dante Alighieri's Inferno.
As fragments of memory return, Langdon pieces together that a brilliant, doom-haunted geneticist named Bertrand Zobrist, obsessed with human overpopulation, has created something he intended to unleash on the world. Following Dante's imagery through Florence, Venice, and Istanbul—hunted by a shadowy security contractor and a World Health Organization team whose motives are unclear—Langdon must decode the trail before a threat with the power to reshape humanity is triggered.
The fourth Robert Langdon novel fuses Renaissance art and Dante scholarship with a modern bioethical thriller, driving toward a moral question with no easy answer.