Series starting with S
- Special Edition Fairies
- Special Education Series
- Species Imperative
- Spectacular Sports
- Spectral Book of Horror Stories
- Spectral Books of Horror Stories
- Spectral Realms
- Spectre Press Chapbooks
- Spectrum
- Spectrum Fantastic Art Live
- Spectrum Music - Based Youth Curriculum
- Spectrum, the Lockwood Thompson Dialogues
- Speedball (Collected Editions)
- Speed of Sound Thriller
- Spellbound
- Spellcrackers.com
- Spells for Life and Death
- Spellslinger
- Spells, Salt, & Steel
- Spellwright
- Spencer-Nyle Co
- Spenser
- Spero Lucas
- SPHDZ
- Spicy Mystery Stories
- Spider-Girl (1998) (Collected Editions)
- Spider-Man 2099: Dark Genesis
- Spider-Man 2099 Omnibus
- Spider-Man/Deadpool
- Spider-Man: Reign
- Spider-Man's Social Dilemma
- Spider-Man: The CCRC Trilogy
- Spider-Man: The Complete Clone Saga
- Spider-Man Visionaries
- Spider-Men
- Spider-Verse
- Spider-Woman (2020) (Collected Editions)
- Spider-Woman: Origin
- SPIE proceedings series
- Spies and Lovers
- SPI Files
- Spike Comics (Buffy Vampire Slayer)
- Spilling CID
- Spin
- Spindle Cove
- Spine Ridge University
- Spirale
- Spirit Animals: Fall of the Beasts
- Spirit Animals: Upadek Bestii
- Spirit Binders
- Spirit Guide Saga
- Spirit Hunters
- Spirits and Thieves
- Spiritual Warfare
- Spiritual Warfare Suspense
- Spiritwalker
- Spirit Walker Series
- Spirou et Fantasio
- Spirou und Fantasio
- Spitfire
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