A
Al Sarrantonio
Mercy Thompson World
Mercy Thompson World is the shared urban-fantasy universe of Patricia Briggs's Mercy Thompson and Alpha & Omega series, read here in a single combined order that interleaves both. Mercy is a coyote shapeshifter and mechanic navigating werewolf packs, vampire politics and fae intrigue; Alpha & Omega follows Anna, an omega werewolf, and Charles, son of the North American Alpha. The two storylines share a world and a cast, and this order places every book in sequence.

The Urban Fantasy Anthology
Mercy Thompson World #0.4
Moon Called
Mercy Thompson #1
Wolfsbane and Mistletoe
Mercy Thompson World #1.1
Alpha and Omega
Alpha and Omega #0.5
On the Prowl
Mercy Thompson World #1.5
Cry Wolf
Alpha and Omega #1
Hunting Ground
Alpha and Omega #2
Blood Bound
Mercy Thompson #2
Iron Kissed
Mercy Thompson #3
Down these strange streets
Mercy Thompson World #5.5
Bone Crossed
Mercy Thompson #4
Silver Borne
Mercy Thompson #5
River Marked
Mercy Thompson #6
Fair Game
Mercy Thompson World #9
Frost Burned
Mercy Thompson #7
Night Broken
Mercy Thompson #8
Dead Heat
Mercy Thompson World #12
Fire Touched
Mercy Thompson #9
Silence Fallen
Mercy Thompson #10
Burn bright
Mercy Thompson World #15
Storm Cursed
Mercy Thompson #11
Smoke Bitten
Alpha & Omega #7
Wild Sign
Alpha and Omega #6
Soul Taken
Mercy Thompson #13
Winter Lost
Mercy Thompson #14
Shifting Shadows
Alpha and Omega #0.1
Instinct
The Dresden FilesThe main series should be read in publication order, starting with Moon Called. There is also a companion collection of short stories, Shifting Shadows, which can be read at any point after the first few books, as it contains stories set at various times within the series timeline.
Yes, the Alpha and Omega series is a spin-off set in the same universe, focusing on different characters. The events and characters from both series occasionally intersect, enriching the overall world-building.
While each book features a self-contained mystery or conflict, there are significant character arcs and developing relationships that build across the entire series. Reading them in order allows for a full appreciation of the evolving world and personal stakes.